More info about sarcomas
http://www.curesarcoma.org/aboutSarcoma.htm
http://www.curesarcoma.org/treatment.htm
Also found on a medical site about all uterus tumors:
"Adenosarcoma is a rare biphasic tumour which may occur at any age. It is a low-grade neoplasm, with a high potential for recurrence and metastasis. It is charaterized by benign epithelial and saromatous mesenchymal components." - there can actually be low grade and high grade tumors, not sure what neopaslam is...This site also says that the high cure rate for cervical/uterine cancers (even the most aggressive ones) is mainly due to the fact that most can be detected via screening, hence at very early stages. This does not hold true for sarcomas.
And why studies and data means very little...Also between 1982 and 1996, there has been some progress in treatment. So as Dr. Powell said "no data fits your case"...which means that doctors don't really know how this tumor will behave.
"Oncol Rep 1998 Jul-Aug;5(4):939-44 Abstract quote
The records of 41 patients diagnosed with adenosarcoma of the female genital tract between 1982 and 1996 were reviewed.
The median age at diagnosis is 51 years (range, 14-84). The most common symptom is vaginal bleeding (71%). Clinical signs at presentation include pelvic mass (37%), uterine polyps (29%), and enlarged uterus (22%). In 71% of patients, the tumor originates from the uterus. Other sites include ovary (15%), pelvis (12%), cervix (2%). [blah blah] Surgery is the mainstay of treatment, but platin-based chemotherapy given upfront in inoperable patient has definite efficacy. An overall response rate of 92.5% was observed after primary therapy (surgery with or without radiotherapy, and/or chemotherapy), with a median survival of 48 months (range, 1-174). Thirty-eight percent of patients had recurrent disease. The median time to recurrence is 12 months (range, 5-132). Although 60% of patients with recurrence achieved a complete remission after treatment, only 1 (8%) is alive without disease, and 3 (22%), with disease at the time of this analysis.
In our series, histologic sarcomatous overgrowth is a predictor of poor prognosis (p<0.03),> Adenosarcoma is a tumor with a fair prognosis. Most tumor can be cured with surgery, but recurrence carries a bad prognosis."
and
"Int J Gynecol Pathol 1995 Jul;14(3):223-9 Abstract quote
The clinical and pathologic features of 12 cervical adenosarcomas from the files of the Armed Forces Institute of Pathology are described.
[some blah blah]
This study demonstrates a favorable prognosis for patients with cervical adenosarcoma. Similar to patients with uterine adenosarcoma, prognosis is mostly affected by the presence of deep myometrial invasion."
http://www.curesarcoma.org/treatment.htm
Also found on a medical site about all uterus tumors:
"Adenosarcoma is a rare biphasic tumour which may occur at any age. It is a low-grade neoplasm, with a high potential for recurrence and metastasis. It is charaterized by benign epithelial and saromatous mesenchymal components." - there can actually be low grade and high grade tumors, not sure what neopaslam is...This site also says that the high cure rate for cervical/uterine cancers (even the most aggressive ones) is mainly due to the fact that most can be detected via screening, hence at very early stages. This does not hold true for sarcomas.
And why studies and data means very little...Also between 1982 and 1996, there has been some progress in treatment. So as Dr. Powell said "no data fits your case"...which means that doctors don't really know how this tumor will behave.
"Oncol Rep 1998 Jul-Aug;5(4):939-44 Abstract quote
The records of 41 patients diagnosed with adenosarcoma of the female genital tract between 1982 and 1996 were reviewed.
The median age at diagnosis is 51 years (range, 14-84). The most common symptom is vaginal bleeding (71%). Clinical signs at presentation include pelvic mass (37%), uterine polyps (29%), and enlarged uterus (22%). In 71% of patients, the tumor originates from the uterus. Other sites include ovary (15%), pelvis (12%), cervix (2%). [blah blah] Surgery is the mainstay of treatment, but platin-based chemotherapy given upfront in inoperable patient has definite efficacy. An overall response rate of 92.5% was observed after primary therapy (surgery with or without radiotherapy, and/or chemotherapy), with a median survival of 48 months (range, 1-174). Thirty-eight percent of patients had recurrent disease. The median time to recurrence is 12 months (range, 5-132). Although 60% of patients with recurrence achieved a complete remission after treatment, only 1 (8%) is alive without disease, and 3 (22%), with disease at the time of this analysis.
In our series, histologic sarcomatous overgrowth is a predictor of poor prognosis (p<0.03),> Adenosarcoma is a tumor with a fair prognosis. Most tumor can be cured with surgery, but recurrence carries a bad prognosis."
and
"Int J Gynecol Pathol 1995 Jul;14(3):223-9 Abstract quote
The clinical and pathologic features of 12 cervical adenosarcomas from the files of the Armed Forces Institute of Pathology are described.
[some blah blah]
This study demonstrates a favorable prognosis for patients with cervical adenosarcoma. Similar to patients with uterine adenosarcoma, prognosis is mostly affected by the presence of deep myometrial invasion."
posted by Finance Monkey at 9:54 AM
0 Comments:
Post a Comment
<< Home